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From: RonO <rokimoto557@gmail.com>
Newsgroups: talk.origins
Subject: Re: RNA sequenced from a Tasmanian tiger specimen
Date: Tue, 17 Sep 2024 06:12:36 -0500
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On 9/16/2024 10:57 PM, Pro Plyd wrote:
> 
> https://www.earth.com/news/rna-recovered-from-an-extinct-species- 
> tasmanian-tiger-for-first-time-ever/
> 
> In a momentous scientific leap, researchers have
> successfully sequenced RNA from an extinct
> Tasmanian tiger specimen that is over a century
> old. This achievement marks a significant
> milestone in the field of genetics and
> paleogenomics.
> 
> For the first time, transcriptomes — essentially
> the complete sets of RNA transcripts from an
> organism — have been reconstructed for an extinct
> species, providing unprecedented insights into the
> biology of the Tasmanian tiger.
> ...
> 
> 
> https://genome.cshlp.org/content/early/2023/07/18/gr.277663.123.abstract
> Historical RNA expression profiles from the
> extinct Tasmanian tiger
> 
> 
It is amazing that they got RNA.  The claim is that the specimen was 
embalmed and desiccated, but they do not say how it was embalmed or what 
chemicals were used.  At this time the best way to preserve RNA in 
tissue is to slice it up into a solution of RNAlater (an RNA 
preservative) and flash freeze the sample.  We would do this at the site 
of collection of the tissue.  RNA is constantly degrading in the living 
animal.  RNA turnover is very high in the living animal, and continues 
after RNA stops being made.  So somehow the embalming process preserved 
enough RNA to sequence using the short read sequencing technology.

Ron Okimoto