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From: RonO <rokimoto557@gmail.com>
Newsgroups: talk.origins
Subject: Antibody negative testing
Date: Sun, 21 Jul 2024 07:07:41 -0500
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https://www.cdc.gov/bird-flu/spotlights/h5n1-response-07192024.html#:~:text=Pasteurization%20kills%20avian%20influenza%20A,and%20should%20take%20proper%20precautions.

The CDC has released results of an initial screen in Michigan of 35 
dairy workers for antibodies to H5N1.  Something seems to be screwy. 
They want to conclude there is no evidence of prior infection with H5N1 
among these 35, but for some stupid reason they did not test the two 
known positives that were identified in Michigan.  The positive controls 
may not have been included, so they do not know if their neutralizing 
test is telling them anything about the dairy infections.  If the two 
positives were included in the 35 and were not found to have 
neutralizing antibodies, that would negate their conclusions.  The 
previous studies that they cite that screened poultry workers for H5N1 
were also negative for neutralizing antibodies, but some of those 
studies found that even though the poultry workers did not pass the 
neutralizing test some workers were detected to have antibodies against 
H5N1.  I do not know why they would not have the known positives in such 
a study.  The CDC claims that the study is being written up for peer review.


QUOTE:
Reporting the preliminary results of the Michigan-led seroprevalence 
investigation. CDC analyzed sera (blood) collected from people who were 
exposed to dairy cattle infected with highly pathogenic avian influenza 
(HPAI) A(H5N1) clade 2.3.4.4b viruses causing outbreaks among animals in 
the United States. These blood samples were collected as part of a type 
of study called a seroprevalence study. Seroprevalence studies test 
people’s blood for antibodies (an immune response) specific to a 
pathogen of interest, in this case HPAI A(H5N1). These studies can tell 
us whether someone has been previously infected.

Blood samples were collected in June 2024 from 35 people who work on 
dairies in Michigan with herds that were confirmed positive for HPAI 
A(H5N1) virus.

Study participants were from multiple counties and had different roles 
on affected farms, but most worked with sick cows directly and fewer 
than half reported using masks or goggles.

These samples were tested for antibodies against an avian influenza 
A(H5N1) clade 2.3.4.4b virus and a seasonal influenza virus (control 
virus) to measure antibodies.

Specimens were tested by two methods: microneutralization and 
hemagglutination inhibition (HI) assays.

None of these 35 people showed neutralizing or HI antibodies (a sign of 
prior infection) specific to avian influenza A(H5N1) virus.

Many of the people had neutralizing antibodies to seasonal flu.

The detection of antibodies to seasonal flu suggests that, not 
unexpectedly, participants in the study had been previously infected or 
vaccinated with seasonal influenza viruses and were able to generate an 
immune response.
END QUOTE:

Ron Okimoto