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From: JAB <here@is.invalid>
Newsgroups: sci.misc
Subject: Switching off PSKH1
Date: Thu, 20 Feb 2025 21:19:34 -0600
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Off switch for known driver of prostate cancer discovered
....
....
Scientists have now figured out how one of the main drivers of
prostate cancer, the enzyme Protein Serine Kinase H1 (PSKH1), can be
switched on, and off.
....
"Tumours form because cells ignore normal signals that tell them it's
time to stop growing, or that it's time to die," says Dr John Scott of
the Monash Institute of Pharmaceutical Sciences (MIPS), joint senior
author of the new study published in the journal PNAS.

"When a signalling molecule, such as PSKH1, interacts with certain
proteins on a cell surface, this binding triggers a chain of events
that can amplify the cell activity and lead to the formation of
tumours."
....
PSKH1 overactivity is associated with tumour progression and
metastasis (spread) in prostate cancer. It is also linked to lung and
kidney cancers.

"Now that we know more about the proteins driving the 'on' and 'off'
status of PSKH1, we can start to develop new drugs that target this
molecule," says Scott.

https://cosmosmagazine.com/science/biology/prostate-cancer-driver/